DONADORAD Project
DONADORAD Project aims to develop a new and efficient in vitro technology to increase the anti-tumor effects of photon or hadron therapy combined with core-shell nanoparticles.
The project has three main objectives:
(i) To synthesize Fe oxide nanoparticles, conjugated with polyethylene glycol, which encapsulate the chemotherapeutic substance doxorubicin.
(ii) To test the radiosensitizing potential of the new nanoparticles in relevant 2D and 3D models, made of cervical carcinoma and chondrosarcoma cells, exposed to photons and hadrons (X-rays, protons with different energies, carbon ions).
(iii) To develop quantitative tools for evaluation of damages induced by ionizing radiations based on hiperspectral images.
The partner teams were led by:
C. S. I Diana Savu Director, from Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH);
Prof. Mona Mihailescu Responsible, from University Politechnica of Bucharest (UPB);